pentobarbital will decrease the level or outcome of fedratinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Outcome of coadministering a solid CYP3A4 inducer with fedratinib has not been researched.pentobarbital will lessen the extent or impact of midostaurin by affecting hepatic/intestinal enzyme CYP3A4